- I graduated with a BSc Pharmacy in Lanzhou University and a MSc Neuroscience in Peking University.
- I am pursuing my PhD studies in the School of Biomedical Sciences, Chinese University of Hong Kong.
- My research project involves the study of emetic mechanisms about TLR4 and opioid receptors.
- Top 10 Most Popular Poster, SBS Research Day, 2022
- Opioid receptors belong to the seven-transmembrane G protein-coupled receptor (GPCR) superfamily, playing critical roles in antinociception and pain management. However, the opioid receptors mediate both emesis and anti-emesis in clinical and animal experiments.
- Toll-like receptor 4 is known to activate immune function which directly leads to inflammation and pain. There is crosstalk signaling pathway between opioid receptors and TLR4. Apart from PAMPs (like viruses, bacteria and fungi) and DAMPs (cell death and tissue damage), TLR4 is also activated by opioid receptors agonists like morphine and inhibited by opioid receptors antagonists like naloxone.
- I hypothesis is that the emetic/ anti-emetic effects of opioid may be mediated by TLR4 (by using Suncus murinus and ferret as animal models).
- My project will involve in animal behavior test, telemetric recording system, microelectrode array technique, plethysmography, Immunohistochemistry, etc.
Ju J, Liu L, Zhang Y, Zhou Q. Effect of age onset on schizophrenia-like phenotypes and underlying mechanisms in model mice. Prog Neuro-psychopharmacol Biol Psychiatry. 2019 Mar 8;89:465-474.