- I am a recent Bachelor of Biomedical Sciences graduate from the Li Ka Shing Faculty of The University of Hong Kong
- Currently, I am pursuing a PhD degree at the School of Biomedical Sciences of The Chinese University of Hong Kong
- My research project focusses on the contribution of disrupted Gastrointestinal Myoelectric Activity (GMA) to the mechanisms of cisplatin-induced acute and delayed nausea and emesis in Ferrets, as a model.
- There are more than 14 million cancer cases each year which are targeted therapeutically by chemotherapy and radiation therapy causing unwanted side effects such as nausea and vomiting.
- Current treatment regimens to tackle these side effects include the use of 5-HT3 receptor antagonists and Tachykinin NK1 receptor antagonists in combination with glucocorticoids however, 20% of the patient population remain unresponsive to these regimens and my project will target this subset of population.
- My research project targets the changes taking place in the gastrointestinal tract during emesis as current drugs targeting the brainstem might not necessarily target and prevent disturbances in the GI tract.
- Our previous studies have shown that slow waves regulating movement in the stomach are simplified after cisplatin treatment therefore, in my project I will be testing various anti-emetics for their potential to restore the slow waves for which I will make use of the radiotelemetry system in Ferrets as a model since they have been proven to have translational value in studies of mechanisms in emesis control.
- I expect to uncover a novel mechanism capable of restoring slow wave signal shape in the stomach which will lead to the prevention of side effects after chemotherapy and result in an improved outcome during cancer treatment.
Kwong, A., Shin, V. Y., Ho, C. Y. S., Khalid, A., Au, C. H., Chan, K. K. L., Ngan, H. Y. S., et al. (2021). Germline PALB2 Mutation in High-Risk Chinese Breast and/or Ovarian Cancer Patients. Cancers, 13(16), 4195. MDPI AG. Retrieved from http://dx.doi.org/10.3390/cancers13164195