Research Interest and PhD project
- I am a research associate in the School of Biomedical Sciences.
- I am interested in emesis research using Suncus murinus and ferret as animal models.
- My PhD project was designed to investigate the anti-emetic potential of the GLP-1 antagonist, exendin (9-39).
- I work on:
- in vitro studies including organ bath and 'grease-gap' techniques were used to characterize the pharmacology of GLP-1 receptor in ferret gut tissues and vagus nerve.
- Western blot was used to investigate the distribution of GLP-1 receptors in the ferret tissues.
- in vivo studies included intracerebroventricular administration of GLP-1 receptor agonist , exendin-4 or exendin (9-39).
- Area postrema ablation surgeries were performed to investigate the role of area postrema in emesis control mechanisms.
- A telemetric recording system was used to record gastric myoelectric activity, heart rate, heart rate variability, blood pressure and body core temperature in freely moving Animals
- A Programmable micro-infusion pump was implanted to enable long-term scheduled drug administration into the brain.
- Immunohistochemistry was used to identify c-fos expression in the ferret brain tissues.
- The Eleventh National Academic Conference of the Chinese Pharmacological Society. Jinan, Shandong Province, China. 22-25 September 2011.
- The Joint International Neurogastroenterology and Motility Meeting. Bologna, Italy. 6-8 September 2012.
- Lu ZB, Zhou Y, Tu LL, Chan SW, Ngan MP, Cui DX, Liu YH, Huang BS, Kung SC, Hui CM & Rudd JA (2020) Sulprostone-induced Gastric Dysrhythmia in the Ferret: Conventional and Advanced Analytical Approaches. Front. Physiol., doi: 10.3389/fphys.2020.583082
- Lu ZB, Chan SW, Tu LL, Ngan MP & Rudd JA (2020). GLP-1 receptors are involved in the GLP-1 (7-36) amide-induced modulation of glucose homoeostasis, emesis and feeding in Suncus murinus (house musk shrew). European Journal of Pharmacology, 888, 173528.
- Lu Z, Ngan MP, Lin G, Yew DTW, Fan X, Andrews PLR, & Rudd JA (2017). Gastric myoelectric activity during cisplatin-induced acute and delayed emesis reveals a temporal impairment of slow waves in ferrets: effects not reversed by the GLP-1 receptor antagonist, exendin (9-39). Oncotarget, In Press.
- Lu Z, Yeung CK, Lin G, Yew DTW, Andrews PLR, & Rudd JA (2017). Insight into the central pathways involved in the emetic and behavioural responses to exendin-4 in the ferret. Autonomic Neurosciences, 202, 122-135.
- Lu Z, Percie du Sert N, Chan SW, Yeung CK, Lin G, Yew DTW, Andrews PLR, & Rudd JA (2015). Differential hypoglycaemic, anorectic, autonomic and emetic effects of the glucagon-like peptide receptor agonist, exendin-4, in the conscious telemetered ferret. Journal of Translational Medicine, 12, 1-13.