- I graduated from BSc Biomedical Engineering in the Hunan University.
- Currently, I’m pursuing a PhD degree in the School of Biomedical Sciences, the Chinese University of Hong Kong.
- My research project is about the action of ghrelin to prevent chemotherapy-induced side effects in Suncus murinus (house musk shrew)
- Ghrelin has well-known appetite stimulating properties, gastric prokinetic activity, and short acting anti-emetic affects against cisplatin-induced emesis in ferrets.
- However, clear anti-emetic effects are only seen following intracerebroventricular (i.c.v.) administration.
- Our previous study showed ghrelin and ghrelin mimetics could antagonize the early emesis induced by the chemotherapeutic drug, cisplatin.
- There are two naturally occurring forms of ghrelin: acyl-ghrelin (AG) and des-acyl-ghrelin (DAG).
- In the present studies, we investigate if both forms of ghrelin can reduce the early and delayed emesis and associated side-effects induced by cisplatin in Suncus murinus following an administration into the brain.