I graduated from Shanghai Jiao Tong University and Xi’an Jiaotong University with a MSc of Biology and a BEng of Biomedical Engineering respectively.
I am pursuing a PhD degree of Biomedical Sciences at the Chinese University of Hong Kong.
My current research project is about novel mechanisms and drug development involved in motion induced emesis.
I am pursuing a PhD degree of Biomedical Sciences at the Chinese University of Hong Kong.
My current research project is about novel mechanisms and drug development involved in motion induced emesis.
Research Interests
1. Motion sickness (MS), which has a prevalence of 1%-60% in the general population, is a common but complex syndrome that may cause nausea or vomiting. People with a history of MS are more likely to undergo emesis upon chemotherapy or general anaesthesia. The current drugs against MS are poorly effective and have unpleasant and/or dangerous adverse effects. These facts lead to a significant interest in researching the mechanisms of MS and developing new drugs.
2. The most widely accepted mechanism of MS is the “sensory-mismatch theory”, in which vestibular system plays a vital role. We focus on the α9α10 nAChRs which receive cholinergic efferents.
3. Suncus murinus, which can show vomiting, is used as model animal. Multiple methods including radiotelemetry, MEA, whole body plethysmography are applied in the research. The research about MS is conducted in molecular, cellular and animal levels from both biological and pharmacological aspects.
2. The most widely accepted mechanism of MS is the “sensory-mismatch theory”, in which vestibular system plays a vital role. We focus on the α9α10 nAChRs which receive cholinergic efferents.
3. Suncus murinus, which can show vomiting, is used as model animal. Multiple methods including radiotelemetry, MEA, whole body plethysmography are applied in the research. The research about MS is conducted in molecular, cellular and animal levels from both biological and pharmacological aspects.
Publications
- Li ZT, Chen YX, Bao H, Liu JT, Zhuang F, Li HP, Yao QP, Qi YX, Platelet-derived microvesicles deliver miR-30e promote VSMC apoptosis after balloon injury, Medicine in Novel Technology and Devices, 2022(13), 100103.
- Li ZT, Yan X, Zhang SM, Bao H, Qi YX, Src/RUNX2 modulates the migration of vascular smooth muscle cells induced by cyclic stretch, Journal of Medical Biomechanics, 2022, 37(2).
- Bao H, Li ZT, Xu LH, Su TY, Han Y, Liu Z, Fan YJ, Lou Y, Chen Y, Jiang ZL, Gong XB, Qi YX, Platelet-derived extracellular vesicles increase Col8a1 secretion and vascular stiffness in intimal injury, Frontiers in Cell and Developmental Biology, 2021 Mar 2;9:641763.
- Liu JT, Bao H, Fan YJ, Li ZT, Yao QP, Han Y, Zhang ML, Jiang ZL, Qi YX. Platelet-derived microvesicles promote VSMC dedifferentiation after intimal injury via Src/Lamtor1/mTORC1 signaling. Frontiers in Cell and Developmental Biology. 2021 Sep 16;9:744320
- Li SS, Gao S, Chen Y, Bao H, Li ZT, Yao QP, Liu JT, Wang YX, Qi YX, Platelet-derived microvesicles induce calcium oscillations and promote VSMC migration via TRPV4, Theranostics, 2021 Jan 1;11(5):2410-2423.
Conferences
1. Li ZT, Qi YX, Jiang ZL, Platelet-derived microvesicles promote VSMC migration after balloon injury via activating oncogene, 2019 China Biomedical Engineering Conference