- Constitutes a group of 6 isoforms involved in tubulin polymerization, microtubule stabilisation and thus axonal transport as well as cytoskeleton signalling.
- Hyperphosphorylation inhibits microtubule assembly promoting instability.
- Extracellular fibrillary tangles are mainly composed of hyperphosphorylated tau. Furthermore, alterations in tau are highly associated with the aging process in humans.
- Recently, a 'tau-axis-hypothesis' links AB and tau pathology. Increasing levels of AB trigger increased phosphorylation of tau. As a consequence tau binding to microtubules is compromised causing accumulation and neuronal toxicity.